Several additional signaling mechanisms namely Ang-1 inhibited the thrombin response by reduction tissue is accomplished, improvement in BOO is limited. In addition, simple TURP does not address the issues of bladder neck contracture due to fibrosis, increased tension from circular fibers in the bladder neck, and chronic prostatitis, which are common physiopathological causes of small volume BPH. TURP may also inadvertently aggravate postoperative bladder neck contracture due to the thermal effect on bladder neck tissue by intraoperative hemostasis and the resection of bladder neck tissue. In the current study, bladder neck contracture was seen in 3 patients undergoing simple TURP, which is consistent with the literature. To avoid the above issues associated with TURP for small volume BPH, we designed STURP, which have several advantages over TURP. First, STURP selectively preserves partial epithelia in the anterior wall of the urinary tract, which increases epithelialization of the urinary tract after surgical trauma, thus minimizing irritation of the surgical wound by urine and reducing scar formation. Second, apart from resection of prostate tissue, STURP effectively relieves bladder neck contracture and lowers bladder neck tension, thereby alleviating BOO, and also avoids the possibility of incisional adhesions from excessive residual gland tissue in transurethral incision of the prostate. Third, STURP preserves the original fibrous tissue between the 2 incisions in the bladder neck and avoids fibrosis of the preserved tissue, further reducing the possibility of bladder neck contracture due to excessive scar formation. In our follow-up of small volume BPH patients, we found that the IPSS in patients receiving STURP was markedly higher than that in patients receiving TURP while STURP was comparable to TURP in operation time, volume of blood loss, and resected prostate gland mass, suggesting that STURP may offer a more effective treatment for small volume BPH without an increase in operative parameters. Given the limited number of patients and length of follow up in this study, the efficacy of STURP for small volume BPH needs to be confirmed by future prospective controlled studies involving a greater number of small volume BPH patients with longer follow-up. STURP is simple to learn and easy to perform, and we believe that STURP may offer a more effective and safer alternative to TURP for small volume BPH patients. Epithelial to mesenchymal transition is a process that enables cancer cells to lose their cell-cell and cell-matrix contacts, gain migratory properties, and become motile mesenchymal cells.Recently, mitochondria have been proven to be highly dynamic organelles that undergo constant fission and fusion, and the balance of these opposing processes regulates the morphology and normal function of mitochondria. Emerging evidence indicates that mitochondrial metabolism is regulated through the manipulation of the proteins involved in mitochondrial dynamics, particularly the Mfn2 protein. Mfn2 is a transmembrane GTPase that is embedded in the outer mitochondrial membrane and is widely expressed in the liver, the heart, and other organs.