In addition, our study demonstrates the feasibility of using genetically modified P. falciparum to study host-parasite interactions in the vector stages of development. The essential role of MAEBL for the sporozoite invasion of the mosquito salivary gland is a weakness in the parasite��s biology that provides a potential opportunity for vectorbased intervention strategies to disrupt malaria transmission. For the last two decades, economically important plants have been genetically transformed for longer shelf life, improved nutritional value, enhanced herbicide tolerance, microbial/insect resistance, and tolerance to various severe environmental stresses. However, when a plant is transformed with a transgene, unexpected and undesirable phenotypes may be produced. Unexpected and undesirable phenotypes are frequently encountered as a result of plant transformation. The reasons for the occurrence of unexpected phenotypes abound. First of all, a transgene could insert into, or adjacent to, plant genes and decrease or increase their expression. Secondly, transformation oculd induce chromosome rearrangements such as deletion, translocation, and inversion during transgene insertion. Finally, transgene insertion is not a precisely Nexturastat A controlled process which could be the reason that transgenic plants with unexpected phenotypes are generated in the first place. Previously, two tomato genes induced by nutrient stress treatments were identified using cDNA arrays, which putatively play a role in plant mineral nutrition uptake or utilization.Whenantisense constructs for the two genes were transformed into tomato plants, one dominant flower mutant was identified from transformation of each construct. While flower structural changes can be caused by mutations in the MADS-box gene family, it is unexpected that antisense to two nutrient stress induced genes would cause mutation in flower structure.As in higher eukaryotes, alternative splicing may be an under appreciated mechanism for the Clopidol expression of different malaria parasite products that could be generating product diversity.