It is possible, therefore, that the period of memory re consolidation can be accelerated by DCS. Moreover, the Desacetyl-asperulosidic-acid findings of these studies with OCD support the idea that the NMDA receptor can become desensitized with prolonged exposure to DCS, and that isolated doses of medication prevent the compensatory changes at the NMDA receptor. Even though DCS did not have more robust effects, accelerating the effects of exposure has important clinical implications. Exposure and response prevention alone require more than 16 sessions to reduce OCD severity. The addition of DCS could reduce to eight the number of sessions. Reducing the required number of sessions and patients responding more quickly to treatment could have benefits to patients and society, such as decrease in treatment refusal, dropout rates, costs, and reduce the anxiety provoked with exposure, facilitating the adherence of treatment. Other hypotheses can also justify the negative findings in OCD, such as the heterogeneity of the disorder and the fact that it is very common for a patient with OCD to be using a Serotonin Reuptake Inhibitor. In the study by Wilhelm et al., 69.5% of the participants were taking a stable dose of some psychotropic medication, in most cases an antidepressant. In Kushner et al., 64.3% of the group that received DCS and 58.8% in the placebo group were using some other psychotropic medication. The use of concomitant medications, usually an antidepressant, could help to explain the negative findings, as antidepressants seem to modify the function of the NMDA receptor. In both studies with social anxiety disorder, we found a higher standardization. Both used the same protocol of 50 mg of DCS one hour Lomitapide Mesylate before CBT sessions 2 to 5, although Hofmann et al. al. used a format of individual or group sessions. Regarding studies with panic disorder both used 50 mg of DCS an hour before the sessions, but differed on the number and format of CBT sessions, which may have influenced the efficacy of DCS in the study with 8 group sessions of Siegmund et al.. With regard to panic disorder, Otto et al. observed statistically significant positive results in the group of DCS as compared to the control group at the end of 5 sessions.