In our finding, C4BPA were up-regulated both in RA and T2D,may indicated the interaction of lots of inflammatory cytokines during both the two disorders. C4BPA was also involved in acute phase response signaling in both RA andT2D in this study, which reported that the highly elevated levels of acute phase proteins at the onset of RA. We found acute phase response signaling also related with T2D patients, with shared DEGs C4BPA andRBP1, which maybe a novel finding ofT2D pathological mechanism. Agranulocyte adhesion and diapedesis were also found shared in RA and T2D, whichis a key event in the process of inflammation and cellular immune response. Agranulocytes response to inflammatory signals such as TNFs, interleukins, complement components and histamine, and then diapedesis passing between neighboring SF1126 endothelial cells to reach the infected tissues. Activated MMPs, such as MMP8and MMP9, which were up-regulated in both RA and T2D in our study, can degrade the Sodium 4-Aminosalicylate assembly of junctional proteins, leading to the opening of inter-endothelial cell contacts, allowing agranulocytes to transmigrate between adjacent endothelial cells to reach the underlying tissue. Many MMPs are expressed at increased levels in RA tissues and in synoviocyte cultures in response to inflammatory cytokines including MMP8, MMP9. There were evidences for the association of MMP9 with type 2 diabetes, but not the case for MMP8. Upregulated MMP8 expression in PBMC in T2D patients may provide novel point inunderstandingT2D. The IL-8 signaling pathway was also identified commonly shared between the RA and the T2Din this study, in which3identified DEGs were in common: DEFA1, MMP9, and MPO. Significant evidence implicates IL-8 as a major mediator of inflammation and joint destruction in rheumatoid arthritis. In response to inflammatory events, activated neutrophils release myeloperoxidase, which is an enzyme producing hypohalousacids for the microbicidal activity of neutrophils. Consistent with previous research, MPO were up-regulated in both RA and T2D patients in our study.