Epidemiological studies investigating the relation between coffee, tea Calindol hydrochloride consumption and caffeine BRD7552 intake and the risk of fractures are fairly abundant in women but scarce in men. Results from the three previous cohort studies in men have shown no association, and a decreased risk of fracture, also summarized in a recent meta-analysis. The incidence of fractures is high in Sweden, also among men. In an international comparison intake of coffee is similarly high in Sweden. Thus, studying the relation between coffee consumption and the risk of fractures in Sweden may be optimal. We recently published results from the so far largest epidemiological study concerning coffee consumption and fracture risk in women. We found that whereas a high coffee consumption is associated with slightly lower bone mineral density, this is not manifested in an increased risk of fracture. We have also previously demonstrated an association between high coffee consumption and a decrease in bone mineral density in older men. Importantly, however, fractures in elderly are not only the consequence of osteoporosis but factors related to the risk of falling are also of importance. The primary aim of this investigation was to study the association between coffee intake and the risk of incident fractures in a large prospective population-based cohort of Swedish men 45�C79 years old at the beginning of the study. A secondary aim was to evaluate whether risk of fracture in relation to coffee consumption was affected by calcium intake. To calculate intake of nutrients the frequency of consumption of each food item was multiplied by the nutrient content of appropriate age-specific portion sizes obtained from the Swedish Food Agency Database. Adjustment of nutrient intake using the residual method was performed for total energy intake. No significant association was found between consumption of coffee and incidence of fractures in this large prospective cohort of Swedish men. Furthermore, this result was not modified by either calcium intake or age. The results from this investigation in men are in line with the results in our recent study of a large cohort of Swedish women. In this study a coffee consumption of cups daily was associated with a decrease in BMD, but this decrease did not translate into an increased risk of fractures.