Nonetheless, from the information currently available and based on our own findings, we can speculate that the SNPs rs9997926 and rs6824447 are related with some functional variant that reduces Elovl6 activity whereas rs17041272 could be linked to a functional variant with the opposite effect. Other limitation of the study concerns the sample size, more studies in bigger population would be necessary to confirm these data. In summary, we found that carriers of the minor alleles rs9997926 and rs6824447 of the ELOVL6 gene have lower insulin resistance than non-carriers and this effect is not independent of the type of oil consumed. This study supports the results of Matsuzaka,BAY-876 suggesting the importance not only of the degree of fatty acid saturation but also of their length on energy metabolism and insulin sensitivity. The experimental results together with those reported here suggest that the ELOVL6 gene could be a future therapeutic target in the treatment of diabetes and related disorders. The Cannabinoid receptors are seven membrane domain receptors of the G-coupled receptor superfamily that are activated by endogenous or exogenous cannabinoids. Among the endocannabinoids, anandamide was the first discovered,K-756 followed by 2-arachidonoylglycerol. Two types of CB receptors are known, type 1 and type 2 : CB1 is predominantly expressed in the central nervous system but also in the lung, liver and kidney, and CB2 in the immune and immune-derived cells.CB2 is also highly expressed in Kupffer cells, resident macrophages in the liver, which, due to their phagocytic activity, play an essential role in the acute and chronic responses of the liver to toxic and infectious agents. A polymorphism at codon 63 of the Cannabinoid Receptor 2 gene leads to the substitution of glutamine, Gln, with arginine, Arg, causing a different polarization state of the protein; the CB2 variants have been demonstrated to affect differently the ability of the CB2 receptor to exert its inhibitory function. Specifically, in-vitro T lymphocytes from CB2-63 RR homozygotes showed an approximately two-fold reduction in the endocannabinoid-induced inhibition of proliferation compared to cells from CB2-63 QQ homozygotes.