Initially designed to comprise an initial exploratory In Silico phase exploiting comparative sequence alignments and subsequent. In Situ hybridization proof of concept phase, the herein presented non-specific results of the exploratory phase made it difficult to conduct parallel confirmatory. In Situ inquiry due to a wide spectrum of test candidates and limited resources. Specifically, contrarily to prior data pointing to an architectural conservation of ribosomal P protein- structure across some life domains, no sequence similarity was found between the acidic termini of T.cruzi ribosomal P proteins TcP0/ TcP2b and sequences of all searched plant, microbial and viral databases by initial NCBI microbial BLAST-P at default. Repeat BLAST at SIB, however, revealed that both C-termini of T. cruzi ribosomal P protein TcP0 and TcP2b exhibit homology to acidic termini of respective eukaryotic proteins. Further, the C-termini of TcP0 and TcP2b are noted to possess characteristic amino acid composition that confer unto them acidity and negative charge. Overall, we provide evidence to suggest that cross reactivity of antibodies against C-terminal sequences of several animal, plant and Yubeinine protozoal ribosomal P proteins with heart tissue may mediate EMF in a similar manner as C- termini of T. cruzi do for Chaga��s disease. It is, never the less, still possible that the mechanisms of molecular mimicry between the suspected EMF-insults and Caudatin myocardial tissue are mediated via different myocardial antigens altogether- thereby, making the specified protein-portions in our study not the likely cause of EMF. Our findings offer the first ever evidence to support the postulate that cross reactivity of antibodies against C-terminal sequences of ribosomal P proteins from several animals, plant and protozoal with heart tissue may mediate EMF in a similar manner as C- termini of T. cruzi do for Chaga��s disease. Overall, despite previous studies implicating several factors in the etiology of EMF, including the evidenced role of ethnicity and suspicions around Infections, allergy, malnutrition and toxic agents as the primary EMF insult; none is yet proven.